L'ofloxacine est la dénomination commune internationale d'un antibiotique de synthèse appartenant à la famille des fluoroquinolones.Son énantiomère actif est la levofloxacine. L'ofloxacine est généralement efficace sur les bactéries Gram-négatives et souvent utilisée dans les infections urinaires et digestives. C'est un antibiotique à large spectre, bactéricide. Ofloxacin (Floxin, Ocuflox) is a moderately priced drug used to treat certain types of bacterial infections.It is slightly more popular than comparable drugs. It is available in generic and brand versions. Generic ofloxacin is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices could be lower. Levofloxacin may be prescribed for those who cannot take Azithromycin. NOTE: Antibiotic use is associated with multi-drug resistant bacteria in the gut of returning travelers. This appears to be transient, but has persisted at a year in approximately 10% of returning travelers and has been transmitted to close household contacts. The impact of the carriage of these multi-drug resistant. Ofloxacin is not subject to degradation by beta-lactamase enzymes nor is it modified by enzymes such as aminoglycoside adenylases or phosphorylases, or chloramphenicol acetyltransferase. 5.2 Pharmacokinetic properties. After ophthalmic instillation, ofloxacin is well maintained in the tear-film. In a healthy volunteer study, mean tear film concentrations of ofloxacin measured four hours after.